• Broker James Caseley 2124006075

310 East 22nd Street 380 Second Ave 1,334 - 3,766 SF of Office/Medical Space Available in New York, NY 10010

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HIGHLIGHTS

  • Centrally Located in “Medical/Education Alley” in close proximity to the leading midtown southeast hospitals and higher education institutions
  • Outpatient Surgery/Ambulatory Surgery Centers permitted
  • Class A Tenant roster of world renowned medical and educational institutions

ALL AVAILABLE SPACES(2)

Display Rental Rate as

  • SPACE
  • SIZE
  • TERM
  • RENTAL RATE
  • SPACE USE
  • CONDITION
  • AVAILABLE
  • 10th Floor, Ste 1002
  • 1,334 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request Upon Request Upon Request
  • Office/Medical
  • Full Build-Out
  • Now
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Floor Plan

• Medical space featuring hardwood floors, good natural light, and north and west views along 2nd Avenue • Existing build-out includes (1) consultation room, (3)exam rooms with sinks and built-in cabinetry, lab room, reception/waiting area, and private restroom Building features: • Tremendous value, Landlord will consider reasonable requests for cosmetic alterations • Join prestigious tenant roster including New York University, Gramercy Surgery Center, New York Eye & Ear Infirmary, School of Visual Arts, NYU Langone • Multiple fiber providers • 24/7/365 Tenant access via two lobbies • Oversized operable windows with impressive natural light • Floors can accommodate significant loads required for medical equipment • Sit-up gurney sized elevators available for use • Long-term stable ownership

  • Fully Built-Out as Standard Medical Space
  • Private Restrooms
  • Drop Ceilings
  • Hardwood Floors
  • Good natural light, north & west exposures
  • Multiple fiber providers, large operable windows
  • Elevator Access
  • Corner Space
  • Natural Light
  • Move-in ready fully builtout corner medical suite
  • 24/7/365 Tenant access via two lobbies
  • Sit-up gurney sized elevators available for use
  • Suites Flyer
  • 10th Floor, Ste 1003
  • 2,432 SF
  • Negotiable
  • Upon Request Upon Request Upon Request Upon Request Upon Request Upon Request
  • Office/Medical
  • Full Build-Out
  • Now
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380 Second Ave, New York, NY for lease - Commercial Listing Video
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380 Second Ave, New York, NY for lease Floor Plan- Image 8 of 8
Floor Plan

• Move-in condition medical space featuring hardwood floors throughout with good natural light offering west views along 2nd Avenue • Existing build-out includes reception area, (2) consultation rooms, (4) exam rooms with built-in exam tables and cabinetry, wet pantry, and storage room • Multiple built-in floor-to-ceiling shelved closets Building features: • Tremendous value, Landlord will consider reasonable requests for cosmetic alterations • Join prestigious tenant roster including New York University, Gramercy Surgery Center, New York Eye & Ear Infirmary, School of Visual Arts, NYU Langone • Multiple fiber providers • 24/7/365 Tenant access via two lobbies • Oversized operable windows with impressive natural light • Floors can accommodate significant loads required for medical equipment • Sit-up gurney sized elevators available for use • Long-term stable ownership

  • Fully Built-Out as Standard Medical Space
  • Corner Space
  • Natural Light
  • Move-in ready fully builtout corner medical suite
  • 24/7/365 Tenant access via two lobbies
  • Floors can accommodate significant loads
  • Reception Area
  • Drop Ceilings
  • Hardwood Floors
  • Good natural light, north & west exposures
  • Multiple fiber providers, large operable windows
  • Sit-up gurney sized elevators available for use
  • Suites Flyer
Space Size Term Rental Rate Space Use Condition Available
10th Floor, Ste 1002 1,334 SF Negotiable Upon Request Upon Request Upon Request Upon Request Upon Request Upon Request Office/Medical Full Build-Out Now
10th Floor, Ste 1003 2,432 SF Negotiable Upon Request Upon Request Upon Request Upon Request Upon Request Upon Request Office/Medical Full Build-Out Now

10th Floor, Ste 1002

Size
1,334 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request Upon Request Upon Request
Space Use
Office/Medical
Condition
Full Build-Out
Available
Now

10th Floor, Ste 1003

Size
2,432 SF
Term
Negotiable
Rental Rate
Upon Request Upon Request Upon Request Upon Request Upon Request Upon Request
Space Use
Office/Medical
Condition
Full Build-Out
Available
Now
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380 Second Ave, New York, NY for lease Interior Photo- Image 1 of 7
Consultation Office
380 Second Ave, New York, NY for lease Interior Photo- Image 2 of 7
Exam Room
380 Second Ave, New York, NY for lease Interior Photo- Image 3 of 7
Exam Room
380 Second Ave, New York, NY for lease Interior Photo- Image 4 of 7
Exam Room
380 Second Ave, New York, NY for lease Interior Photo- Image 5 of 7
Reception/waiting area
380 Second Ave, New York, NY for lease Interior Photo- Image 6 of 7
Reception/waiting area
380 Second Ave, New York, NY for lease Floor Plan- Image 7 of 7
Floor Plan

10th Floor, Ste 1002

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380 Second Ave, New York, NY for lease Interior Photo- Image 1 of 7
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380 Second Ave, New York, NY for lease Interior Photo- Image 6 of 7
Interior Photo
380 Second Ave, New York, NY for lease Floor Plan- Image 7 of 7
Floor Plan
Size 1,334 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office/Medical
Condition Full Build-Out
Available Now

• Medical space featuring hardwood floors, good natural light, and north and west views along 2nd Avenue • Existing build-out includes (1) consultation room, (3)exam rooms with sinks and built-in cabinetry, lab room, reception/waiting area, and private restroom Building features: • Tremendous value, Landlord will consider reasonable requests for cosmetic alterations • Join prestigious tenant roster including New York University, Gramercy Surgery Center, New York Eye & Ear Infirmary, School of Visual Arts, NYU Langone • Multiple fiber providers • 24/7/365 Tenant access via two lobbies • Oversized operable windows with impressive natural light • Floors can accommodate significant loads required for medical equipment • Sit-up gurney sized elevators available for use • Long-term stable ownership

  • Fully Built-Out as Standard Medical Space
  • Elevator Access
  • Private Restrooms
  • Corner Space
  • Drop Ceilings
  • Natural Light
  • Hardwood Floors
  • Move-in ready fully builtout corner medical suite
  • Good natural light, north & west exposures
  • 24/7/365 Tenant access via two lobbies
  • Multiple fiber providers, large operable windows
  • Sit-up gurney sized elevators available for use
  • Suites Flyer
1 of 9
VIDEOS
3D TOUR
PHOTOS
STREET VIEW STREET
MAP
1/9
380 Second Ave, New York, NY for lease Interior Photo- Image 1 of 8
Reception Area
380 Second Ave, New York, NY for lease Interior Photo- Image 2 of 8
Interior Photo
380 Second Ave, New York, NY for lease Interior Photo- Image 3 of 8
Exam Room
380 Second Ave, New York, NY for lease Interior Photo- Image 4 of 8
Exam Room
380 Second Ave, New York, NY for lease Interior Photo- Image 5 of 8
Exam Room
380 Second Ave, New York, NY for lease Interior Photo- Image 6 of 8
Built-in Storage Closets
380 Second Ave, New York, NY for lease Interior Photo- Image 7 of 8
Wet Pantry
380 Second Ave, New York, NY for lease Floor Plan- Image 8 of 8
Floor Plan

10th Floor, Ste 1003

1/9
380 Second Ave, New York, NY for lease - Commercial Listing Video
380 Second Ave, New York, NY for lease Interior Photo- Image 1 of 8
Interior Photo
380 Second Ave, New York, NY for lease Interior Photo- Image 2 of 8
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380 Second Ave, New York, NY for lease Interior Photo- Image 3 of 8
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380 Second Ave, New York, NY for lease Interior Photo- Image 4 of 8
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380 Second Ave, New York, NY for lease Interior Photo- Image 5 of 8
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380 Second Ave, New York, NY for lease Interior Photo- Image 6 of 8
Interior Photo
380 Second Ave, New York, NY for lease Interior Photo- Image 7 of 8
Interior Photo
380 Second Ave, New York, NY for lease Floor Plan- Image 8 of 8
Floor Plan
Size 2,432 SF
Term Negotiable
Rental Rate Upon Request
Space Use Office/Medical
Condition Full Build-Out
Available Now

• Move-in condition medical space featuring hardwood floors throughout with good natural light offering west views along 2nd Avenue • Existing build-out includes reception area, (2) consultation rooms, (4) exam rooms with built-in exam tables and cabinetry, wet pantry, and storage room • Multiple built-in floor-to-ceiling shelved closets Building features: • Tremendous value, Landlord will consider reasonable requests for cosmetic alterations • Join prestigious tenant roster including New York University, Gramercy Surgery Center, New York Eye & Ear Infirmary, School of Visual Arts, NYU Langone • Multiple fiber providers • 24/7/365 Tenant access via two lobbies • Oversized operable windows with impressive natural light • Floors can accommodate significant loads required for medical equipment • Sit-up gurney sized elevators available for use • Long-term stable ownership

  • Fully Built-Out as Standard Medical Space
  • Reception Area
  • Corner Space
  • Drop Ceilings
  • Natural Light
  • Hardwood Floors
  • Move-in ready fully builtout corner medical suite
  • Good natural light, north & west exposures
  • 24/7/365 Tenant access via two lobbies
  • Multiple fiber providers, large operable windows
  • Floors can accommodate significant loads
  • Sit-up gurney sized elevators available for use
  • Suites Flyer

PROPERTY OVERVIEW

Centrally located in the midtown southeast submarket of NYC, 380 Second Avenue has become a highly desired address for departments of leading medical and educational institutions in the surrounding area. Tenants include New York University’s Department of Physical Therapy and College of Dentistry, NYU Langone Hospital’s Diagnostic Imaging Center and Hospital for Joint Diseases, Mt. Sinai’s New York Eye & Ear Infirmary and, School of Visual Arts to name a few. The building was recently branded “The Gramercy Medical Arts Building” due to its mix of world- renowned tenants in the fields of healthcare, the arts and education. 380 Second Avenue stands 10 stories tall, consisting of 20,000 rentable square foot floor plates. The property features 300 pound floor loads, two handicapped accessible lobbies and, a private loading dock on 22nd Street. Each floor benefits from natural light, with the top three floors showcasing excellent views of the NYC skyline.

  • 24 Hour Access
  • Bio-Tech/ Lab Space
  • Bus Line
  • Concierge
  • Metro/Subway
  • Property Manager on Site
  • Security System
  • Signage
  • Central Heating
  • High Ceilings
  • Direct Elevator Exposure
  • Natural Light
  • Plug & Play
  • Wi-Fi
  • Air Conditioning

PROPERTY FACTS

Building Type
Office
Year Built
1909
Building Height
10 Stories
Building Size
200,000 SF
Building Class
B
Typical Floor Size
20,000 SF
Unfinished Ceiling Height
12’
Parking
Surface Parking
Surface Tandem Parking
Covered Parking
Covered Tandem Parking
Reserved Parking

SELECT TENANTS

  • FLOOR
  • TENANT NAME
  • INDUSTRY
  • LL
  • Eastside Endoscopy
  • Health Care and Social Assistance
  • 10th
  • Gramercy Surgery Center
  • Health Care and Social Assistance
  • 9th
  • New York Eye & Ear Infirmary
  • Health Care and Social Assistance
  • GRND
  • NYU Langone Radiology
  • Health Care and Social Assistance
  • Multiple
  • School Of Visual Arts
  • Information

ATTACHMENTS

Suites Flyer
Walk Score®
Walker's Paradise (100)
Transit Score®
Rider's Paradise (100)
Bike Score®
Biker's Paradise (94)

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ADDITIONAL PHOTOS

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  • Listing ID: 13965464

  • Date on Market: 6/13/2025

  • Last Updated: 6/13/2025

  • Address: 380 Second Ave, New York, NY 10010